Treatment Trials

3 Clinical Trials for Various Conditions

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      COMPLETED
      Phase II Trial of Natalizumab + Prednisone for Initial Therapy of Acute GI GVHD
      Description

      This research study is a Phase II clinical trial, which tests the safety and effectiveness of an investigational drug Natalizumab in treating Acute Graft-Versus-Host Disease (GVHD) in the Gastrointestinal (GI) Tract.

      Conditions
      Graft Versus Host Disease
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      TERMINATED
      A Phase 2A Study of ALXN1007 in Participants With Newly Diagnosed Acute Lower Gastrointestinal Graft-Versus-Host Disease
      Description

      The objectives of this trial were to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics (PK/PD) and efficacy of intravenous (IV) ALXN1007 in participants with acute graft-versus-host disease (GVHD) of the lower gastrointestinal (GI) tract.

      Conditions
      Acute Graft-Versus-Host DiseaseGIGVHD
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      TERMINATED
      Proof-of-concept Trial of Apraglutide in GVHD
      Description

      The aim of this trial is to assess safety and efficacy of apraglutide in subjects with steroid refractory gastrointestinal acute graft versus host disease (aGVHD).

      Conditions
      GVHD
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