Treatment Trials

3 Clinical Trials for Various Conditions

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      COMPLETED
      Phase II Study of Tipifarnib in Squamous Head and Neck Cancer With HRAS Mutations
      Description

      Phase II study to investigate the antitumor activity in terms of objective response rate (ORR) of tipifarnib in subjects with advanced tumors that carry HRAS mutations and for whom there is no standard curative therapy available.

      Conditions
      Thyroid CancerSquamous Cell Carcinoma Head and Neck Cancer (HNSCC)HRAS Mutant TumorOther Squamous Cell Carcinoma (SCC) With HRAS Mutant Tumor
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      COMPLETED
      A Study of ASN007 in Patients With Advanced Solid Tumors
      Description

      The study is divided into two parts. The first part of the study will test various doses of ASN007 to find out the highest safe dose to test in five specific groups. The second part of the study will test how well ASN007 can control cancer.

      Conditions
      CancerMalignancyNeoplasiaNeoplasmNeoplasm MetastasisColon CancerColonic NeoplasmsColon Cancer Liver MetastasisMetastatic CancerMetastatic MelanomaMetastatic Colon CancerMetastatic Lung CancerNon Small Cell Lung Cancer MetastaticPancreatic CancerPancreas CancerPancreas AdenocarcinomaPancreas NeoplasmMetastatic Nonsmall Cell Lung CancerMetastatic Pancreatic Cancer
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      COMPLETED
      A Study of IMM-6-415 in RAS/RAF Mutant Solid Tumors
      Description

      This is a FIH, ascending dose study to characterize the safety, tolerability, optimal dose and preliminary anti-tumor activity of IMM-6-415 in participants with advanced or metastatic solid tumors harboring RAS or RAF oncogenic mutations.

      Conditions
      Advanced Solid Tumor (Phase 1)Pancreas AdenocarcinomaNon-small Cell Lung CancerMalignant Melanoma (Cutaneous)
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