Treatment Trials

4 Clinical Trials for Various Conditions

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      COMPLETED
      Clinical Study of Cefiderocol (S-649266) for the Treatment of Nosocomial Pneumonia Caused by Gram-negative Pathogens
      Description

      The primary objective of this study is to compare all-cause mortality at Day 14 in participants receiving cefiderocol with participants receiving the comparator, meropenem, in adults with hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), or healthcare-associated bacterial pneumonia (HCABP) caused by Gram-negative pathogens.

      Conditions
      Healthcare-associated Pneumonia (HCAP)Hospital Acquired Pneumonia (HAP)Ventilator Associated Pneumonia (VAP)
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      COMPLETED
      Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens
      Description

      This study is designed to provide evidence of efficacy of cefiderocol in the treatment of serious infections in adult patients caused by carbapenem-resistant Gram-negative pathogens.

      Conditions
      Healthcare-associated Pneumonia (HCAP)Bloodstream Infections (BSI)Hospital Acquired Pneumonia (HAP)Complicated Urinary Tract Infection (cUTI)SepsisVentilator Associated Pneumonia (VAP)
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      COMPLETED
      Identifying Risk Factors for Gram-negative Resistance for HAP/VAP in the Intensive Care Unit
      Description

      Single center, retrospective chart review. Patients admitted to MDMC ICU from 4/1/2017 to 6/30/2020 will be identified through the electronic medical record utilizing ICD codes for HAP and VAP.

      Conditions
      Ventilator-associated PneumoniaHospital-acquired Pneumonia
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      COMPLETED
      Targeting Platelet-Leukocyte Aggregates in Pneumonia With Ticagrelor
      Description

      The hypothesis to be tested is that ticagrelor (Brilinta™) will reduce platelet activation and markers of inflammation in patients with pneumonia.

      Conditions
      PneumoniaCommunity Acquired PneumoniaHospital Acquired PneumoniaAcute Lung Injury
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