Treatment Trials

2 Clinical Trials for Various Conditions

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      RECRUITING
      Immune Disorder HSCT Protocol
      Description

      This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

      Conditions
      Immune Deficiency DisordersSevere Combined ImmunodeficiencyChronic Granulomatous DiseaseX-linked AgammaglobulinemiaWiskott-Aldrich SyndromeHyper-IgMDiGeorge SyndromeChediak-Higashi SyndromeCommon Variable Immune DeficiencyImmune Dysregulatory DisordersHemophagocytic LymphohistiocytosisIPEXAutoimmune Lymphoproliferative SyndromeX-linked Lymphoproliferative Syndrome
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      RECRUITING
      Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide
      Description

      This is a Phase II prospective trial to assess the rates of donor engraftment using reduced intensity conditioning (RIC) hematopoietic stem cell transplant (HSCT) and post-transplant cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

      Conditions
      Primary Immune Deficiency DisorderImmune Deficiency DiseaseBone Marrow Failure
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