Treatment Trials

2 Clinical Trials for Various Conditions

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      TERMINATED
      Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial Dysfunction
      Description

      This study is designed to assess the safety and efficacy of twice-daily oral dosing of 6R-BH4 to improve endothelial function, reduce systolic blood pressure and reduce arterial stiffness.

      Conditions
      Isolated Systolic HypertensionEndothelial Dysfunction
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      COMPLETED
      STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH
      Description

      Determine whether increasing arterial distensibility by decreasing advanced glycation end-product (AGE) cross-link components of vascular stiffness improves (a) endothelial-mediated vasoreactivity at rest, as assessed by flow-mediated vasodilation (FMD), and (b) endothelial-mediated vasoreactivity after exercise, as assessed by pulse perfusion-mediated vasodilation (PPMV).

      Conditions
      Cardiovascular Disease
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