Treatment Trials

3 Clinical Trials for Various Conditions

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      TERMINATED
      Study of Saxagliptin, 5-Hydroxy Saxagliptin, and Metformin Concentrations/Levels in Pediatric Subjects With T2DM
      Description

      The purpose of this study is to evaluate the pharmacokinetics of Saxagliptin, 5-hydroxy Saxagliptin, and Metformin in pediatric subjects with Type 2 diabetes mellitus (T2DM) following oral administration of Saxagliptin and Metformin XR fixed dose combination tablet and co-administration of Saxagliptin and Glucophage® (Metformin) IR tablets

      Conditions
      Type 2 Diabetes Mellitus
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      COMPLETED
      Dietary Intake of Tryptophan and Metformin Response
      Description

      This study will examine the influence of dietary intake of tryptophan on response to metformin. The investigators hypothesize that dietary tryptophan alteration will influence metformin response.

      Conditions
      Metformin ResponseFasting GlucoseTryptophan ConcentrationMetformin ConcentrationDiet Tolerability
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      COMPLETED
      Assessing the PK and Effect on Glucose and GI Hormone Concentrations of Metformin Delayed-Release in Subjects With T2DM
      Description

      This study will evaluate how EFB0027 and EFB0026 behave in subjects with type 2 diabetes mellitus. In addition, this study will compare the effects of EFB0027 and EFB0026 on circulating concentrations of glucose and gastrointestinal hormones in subjects with type 2 diabetes mellitus.

      Conditions
      Type 2 Diabetes Mellitus
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