Treatment Trials

2 Clinical Trials for Various Conditions

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      COMPLETED
      Mechlorethamine Induced Contact Dermatitis Avoidance Study
      Description

      This is a two-arm, open-label study that aims to compare the incidence and severity of the most common adverse reactions, particularly contact dermatitis, when Valchlor is used alone or in conjunction with triamcinolone ointment 0.1% in early stage MF subjects (Stage IA and IB) for a period of 4 months.

      Conditions
      Cutaneous T-cell LymphomaCutaneous T-cell Lymphoma Stage IMycosis FungoidesFolliculotropic Mycosis FungoidesGranulomatous Slack SkinSyringotropic Mycosis FungoidesMycosis Fungoides VariantTransformed Mycosis Fungoides
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      ACTIVE_NOT_RECRUITING
      Anti-ICOS Monoclonal Antibody MEDI-570 in Treating Patients With Relapsed or Refractory Peripheral T-cell Lymphoma Follicular Variant or Angioimmunoblastic T-cell Lymphoma
      Description

      This phase I trial studies the side effects and best dose of anti-inducible T-cell co-stimulator (ICOS) monoclonal antibody MEDI-570 in treating patients with peripheral T-cell lymphoma follicular variant or angioimmunoblastic T-cell lymphoma that has returned after a period of improvement (relapsed) or has not responded to previous treatment (refractory). Immunotherapy with monoclonal antibodies, such as anti-ICOS monoclonal antibody MEDI-570, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread.

      Conditions
      Advanced Primary Cutaneous T-Cell Non-Hodgkin LymphomaRecurrent Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-TypeRecurrent Grade 1 Follicular LymphomaRecurrent Grade 2 Follicular LymphomaRecurrent Grade 3a Follicular LymphomaRecurrent Mature T-Cell and NK-Cell Non-Hodgkin LymphomaRecurrent Mycosis FungoidesRecurrent Primary Cutaneous T-Cell Non-Hodgkin LymphomaRefractory Follicular Helper T-Cell Lymphoma, Angioimmunoblastic-TypeRefractory Grade 1 Follicular LymphomaRefractory Grade 2 Follicular LymphomaRefractory Grade 3a Follicular LymphomaRefractory Mature T-Cell and NK-Cell Non-Hodgkin LymphomaStage IB Mycosis Fungoides AJCC v7Stage II Mycosis Fungoides AJCC v7Stage III Cutaneous T-Cell Non-Hodgkin LymphomaStage III Mycosis Fungoides AJCC v7Stage IV Cutaneous T-Cell Non-Hodgkin LymphomaStage IV Mycosis Fungoides AJCC v7
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