Treatment Trials

3 Clinical Trials for Various Conditions

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      TERMINATED
      Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma
      Description

      This phase II trial is studying how well gamma-secretase/Notch signalling pathway inhibitor RO4929097 works in treating patients with stage IV melanoma. Gamma-secretase/Notch signalling pathway inhibitor RO4929097 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

      Conditions
      Acral Lentiginous Malignant MelanomaLentigo Maligna Malignant MelanomaNodular Malignant MelanomaRecurrent MelanomaSolar Radiation-related Skin MelanomaStage IV MelanomaSuperficial Spreading Malignant Melanoma
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      ACTIVE_NOT_RECRUITING
      Dinaciclib in Treating Patients With Stage IV Melanoma
      Description

      This phase II trial is studying the side effects and how well dinaciclib works in treating patients with stage IV melanoma. Dinaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

      Conditions
      Acral Lentiginous MelanomaCutaneous Nodular MelanomaLentigo Maligna MelanomaLow-CSD MelanomaMucosal MelanomaRecurrent MelanomaStage IV Cutaneous Melanoma AJCC v6 and v7
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      COMPLETED
      Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma
      Description

      RATIONALE: Inserting a modified herpesvirus gene into a person's melanoma cells may make the cancer more sensitive to the antiviral agent ganciclovir. PURPOSE: Phase I trial to study the effectiveness of gene therapy in treating patients who have stage IV melanoma.

      Conditions
      Melanoma (Skin)
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