Treatment Trials

7 Clinical Trials for Various Conditions

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      COMPLETED
      Withdrawal Study to Demonstrate the Maintenance Effect in the Treatment of Non-24-Hour Sleep-Wake Disorder
      Description

      The purpose of this study is to evaluate the maintenance effect and safety of 20 mg tasimelteon versus placebo in subjects suffering from Non-24-Hour Sleep-Wake Disorder.

      Conditions
      Non-24-Hour Sleep-Wake Disorder
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      COMPLETED
      Tasimelteon for the Treatment of Non-24-hour Sleep-Wake Disorder (N24HSWD) in Blind Individuals With no Light Perception
      Description

      The purpose of this study is to evaluate the safety of tasimelteon in male and female patients who suffer from Non-24-Hour Sleep-Wake Disorder.

      Conditions
      Non-24-Hour Sleep-Wake Disorder
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      COMPLETED
      Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Disorder
      Description

      The purpose of this study is to evaluate the efficacy and safety of a six month double-mask treatment of tasimelteon or placebo in male and female subjects with Non-24-Hour Sleep-Wake Disorder

      Conditions
      Non-24-Hour Sleep-Wake Disorder
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      COMPLETED
      Efficacy and Safety of Circadin for Non-24 Hour Sleep-Wake Disorder in Totally Blind Subjects
      Description

      The aim of this placebo-controlled randomized study was to evaluate the efficacy of Circadin™ 2 mg in improving total night sleep duration and stabilizing the circadian clock phase in totally blind subjects with non-24 hour sleep-wake disorder.

      Conditions
      Non-24 Hour Sleep-Wake DisorderBlindness
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      ACTIVE_NOT_RECRUITING
      Breath Biomarkers for Sleep Loss and Circadian Timing
      Description

      Insufficient sleep has both health and safety risks, but currently there are no quick, accurate and inexpensive ways to measure sleep deficiency. The current study aims to use a cutting-edge technology, small molecule analysis (e.g. metabolomics), to detect compounds in breath that reliably change with sleep-wake state and those whose levels vary by time of day.

      Conditions
      Shift-Work Sleep DisorderShift Work Type Circadian Rhythm Sleep DisorderSleep Disorders, Circadian RhythmSleep Disorders, IntrinsicAdvanced Sleep Phase Syndrome (ASPS)Advanced Sleep Phase SyndromeAdvanced Sleep PhaseDelayed Sleep PhaseDelayed Sleep Phase SyndromeNon-24 Hour Sleep-Wake DisorderIrregular Sleep-Wake Syndrome
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      ACTIVE_NOT_RECRUITING
      Biomarkers for Circadian Timing in Healthy Adults
      Description

      Study investigators want to learn more about the underlying biological clock and to see if the timing of that clock can be estimated from a single blood sample.

      Conditions
      Sleep Wake DisordersSleep Disorders, Circadian RhythmSleep Disorders, IntrinsicAdvanced Sleep Phase Syndrome (ASPS)Advanced Sleep Phase SyndromeAdvanced Sleep PhaseDelayed Sleep PhaseDelayed Sleep Phase SyndromeNon-24 Hour Sleep-Wake DisorderIrregular Sleep-Wake SyndromeShift-Work Sleep DisorderShift Work Type Circadian Rhythm Sleep DisorderDelayed Phase Sleep Syndrome
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      COMPLETED
      Study of the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents
      Description

      Open-label Study to Investigate the Pharmacokinetics and Safety of Tasimelteon in Children and Adolescents.

      Conditions
      Circadian Rhythm Sleep DisordersNon-24 Hour Sleep-Wake DisorderAutism Spectrum DisorderSmith-Magenis Syndrome
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