Treatment Trials

4 Clinical Trials for Various Conditions

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      COMPLETED
      Repeated Infusions of Mesenchymal Stromal Cells in Children With Osteogenesis Imperfecta
      Description

      This is a study to evaluate the safety and effectiveness of repeated Mesenchymal Stromal Cells (MSC) infusions to patients with Type II or III osteogenesis imperfecta (OI). Participants will receive MSC infusions approximately every 4 months to complete a total of 6 infusions over 20 months. Participants will be followed for 4 months post their last MSC infusion.

      Conditions
      Osteogenesis Imperfecta Type IIOsteogenesis Imperfecta Type III
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      COMPLETED
      A Study in Adult Patients With Type I, III or IV Osteogenesis Imperfecta Treated With BPS804
      Description

      The purpose of this study is to select a suitable dose of BPS804 by measuring the strength/quality of bone using a special type of CT scanner. Participants will be treated for 12 months and followed up for a further 12 months.

      Conditions
      Osteogenesis Imperfecta, Type IOsteogenesis Imperfecta Type IIIOsteogenesis Imperfecta Type IV
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      TERMINATED
      Long-term Extension Study of Setrusumab in Adults With Type I, III, or IV Osteogenesis Imperfecta
      Description

      The primary objective of the study is to evaluate bone mineral density (BMD) after 12 months of retreatment with monthly setrusumab in adults with osteogenesis imperfecta (OI).

      Conditions
      Osteogenesis Imperfecta
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      WITHDRAWN
      An Exploratory Study of BPS804 Treatment in Adult Patients With Type I, III or IV Osteogenesis Imperfecta
      Description

      The purpose of this study is to investigate the effect of BPS804 on strength/quality of bone in patients with Type I, III or IV Osteogenesis imperfecta using a special type of CT scanner. Participants will be treated for 1 year.

      Conditions
      Osteogenesis Imperfecta
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