Treatment Trials

2 Clinical Trials for Various Conditions

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      RECRUITING
      A Study of GV20-0251 Monotherapy and GV20-0251 in Combination with Pembrolizumab in Participants with Solid Tumor Malignancies
      Description

      This is a Phase 1/2A study of GV20-0251 being developed for the treatment of participants with advanced solid tumors, who are refractory to approved therapies or other standard of care.

      Conditions
      Solid Tumor, AdultRefractory CancerEndometrial Carcinoma (EC)Squamous Head and Neck CarcinomaPMMR/MSS Adenocarcinoma of the Colon or RectumCutaneous MelanomaNon-Small Cell Lung Cancer
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      TERMINATED
      Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer
      Description

      This clinical trial will be conducted as a single-center, open-label, Phase I/2 trial to evaluate the feasibility and safety of Yttrium-90 radioembolization (Y90-RE) in combination with a fixed dose of of immunotherapy (durvalumab - 750 mg) in subjects with liver-predominant, metastatic colorectal cancer (mCRC), which is mismatch repair proficient/microsatellite stable (pMMR/MSS).

      Conditions
      Colorectal Cancer MetastaticColon CancerMetastatic Colorectal CancerRectal CancerLiver Metastasis Colon CancerColo-rectal CancerColorectal AdenocarcinomaColorectal NeoplasmsLiver MetastasesColorectal Carcinoma
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