Treatment Trials

2 Clinical Trials for Various Conditions

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      COMPLETED
      Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
      Description

      Frontotemporal Lobar Degeneration (FTLD) is the neuropathological term for a collection of rare neurodegenerative diseases that correspond to four main overlapping clinical syndromes: frontotemporal dementia (FTD), primary progressive aphasia (PPA), corticobasal degeneration syndrome (CBS) and progressive supranuclear palsy syndrome (PSPS). The goal of this study is to build a FTLD clinical research consortium to support the development of FTLD therapies for new clinical trials. The consortium, referred to as Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL), will be headquartered at UCSF and will partner with six patient advocacy groups to manage the consortium. Participants will be evaluated at 14 clinical sites throughout North America and a genetics core will genotype all individuals for FTLD associated genes.

      Conditions
      FTLDProgressive Supranuclear Palsy (PSP)Frontotemporal Dementia (FTD)Corticobasal Degeneration (CBD)PPA SyndromeBehavioral Variant Frontotemporal Dementia (bvFTD)Semantic Variant Primary Progressive Aphasia (svPPA)Nonfluent Variant Primary Progressive Aphasia (nfvPPA)FTD With Amyotrophic Lateral Sclerosis (FTD/ALS)Amyotrophic Lateral Sclerosis (ALS)Oligosymptomatic PSP (oPSP)Corticobasal Syndrome (CBS)
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      RECRUITING
      UPenn Observational Research Repository on Neurodegenerative Disease
      Description

      The aim of this study is to create a repository of both cross-sectional and longitudinal data, including cognitive, linguistic, imaging and biofluid biological specimens, for neurodegenerative disease research and treatment.

      Conditions
      Frontotemporal Degeneration(FTD)Primary Progressive Aphasia(PPA)Familial Frontotemporal Lobar Degeneration (fFTLD)Amyotrophic Lateral Sclerosis(ALS)Lewy Body Disease(LBD)Progressive Supranuclear Palsy(PSP)Corticobasal Syndrome(CBS)Posterior Cortical Atrophy(PCA)Alzheimer's Disease(AD)
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