This study is designed to enable optimal dose selection of LFF269 for potential future studies by providing additional information about the compounds safety, tolerability, pharmacokinetic and pharmacodynamic profiles.

To Evaluate Pharmacokinetics of LFF269 in Healthy Volunteers and Patients With Hypertension

A Two Part Study Including a Randomized, Double Blind, Placebo Controlled, Multiple Dose Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LFF269 After b.i.d Dosing in Healthy Volunteers and an Open Label, Multiple Dose Pharmacokinetics Study in Hypertension Subjects

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To Evaluate Pharmacokinetics of LFF269 in Healthy Volunteers and Patients With Hypertension

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