Treatment Trials

3 Clinical Trials for Various Conditions

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      TERMINATED
      BIIB092 in Primary Tauopathies: CBS, nfvPPA, sMAPT, and TES
      Description

      A Phase 1b, Randomized, Double-Blind, Placebo-Controlled, Parallel Cohort Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy Study of Intravenously Infused BIIB092 in Patients with Four Different Primary Tauopathy Syndromes

      Conditions
      Primary TauopathiesCorticobasal Degeneration SyndromeFrontotemporal Lobar Degeneration With Tau InclusionsMAPT Mutation Carriers, SymptomaticTraumatic Encephalopathy SyndromeNonfluent Aphasia, Progressive
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      COMPLETED
      Safety Study of TPI-287 to Treat CBS and PSP
      Description

      The purpose of this study is to determine the safety and tolerability \[maximum tolerated dose (MTD) within planned dosing range\] of intravenous (IV) infusions of TPI 287 administered once every 3 weeks for 9 weeks (for a total of 4 infusions) in patients with primary four repeat tauopathies (4RT), corticobasal syndrome (CBS; also called corticobasal degeneration, CBD) or progressive supranuclear palsy (PSP).

      Conditions
      Primary Four Repeat Tauopathies (4RT)Corticobasal Syndrome (CBS)Progressive Supranuclear Palsy (PSP)Corticobasal Degeneration (CBD)
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      COMPLETED
      4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2
      Description

      The goal of this study is to identify the most reliable methods of analysis for tracking CBD, PSP, and o/vPSP over time. The results from this study may be used in the future to calculate statistical power for clinical drug trials. The study will also provide information about the relative value of novel imaging techniques for diagnosis, as well as the value of imaging techniques versus testing of blood, urine, and cerebrospinal fluid (CSF) 'biomarkers'.

      Conditions
      Corticobasal Degeneration (CBD)Corticobasal Syndrome (CBS)Cortical-basal Ganglionic Degeneration (CBGD)Progressive Supranuclear Palsy (PSP)Nonfluent Variant Primary Progressive Aphasia (nfvPPA)Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)
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