Treatment Trials

2 Clinical Trials for Various Conditions

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      TERMINATED
      A Study of Alectinib in RET-rearranged Non-small Cell Lung Cancer or RET-mutated Thyroid Cancer
      Description

      This research trial is studying a drug called alectinib as a possible treatment for non-small cell lung cancer (NSCLC) with specific genetic alterations known as ALK or RET rearrangements, and thyroid cancer with RET rearrangements.

      Conditions
      ALK-positive Non-small Cell Lung Cancer (NSCLC)RET-positive Non-small Cell Lung Cancer (NSCLC)RET-positive Thyroid Cancer
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      COMPLETED
      Phase 1/2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Participants With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors
      Description

      This is a Phase 1/2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in participants with medullary thyroid cancer (MTC), RET-altered NSCLC and other RET-altered solid tumors.

      Conditions
      RET-altered Non Small Cell Lung CancerMedullary Thyroid CancerRET-altered Papillary Thyroid CancerRET-altered Colon CancerRET-altered Solid TumorsLung NeoplasmCarcinoma, Non-Small-Cell LungThyroid DiseasesThyroid NeoplasmThyroid Cancer, PapillaryCarcinoma, NeuroendocrineRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by SiteNeoplasmsLung DiseasesRespiratory Tract DiseaseCarcinoma, BronchogenicBronchial NeoplasmsEndocrine System DiseasesEndocrine Gland NeoplasmHead and Neck NeoplasmsAdenocarcinoma, PapillaryAdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeuroendocrine TumorsNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms, Nerve TissueColonic NeoplasmsColorectal NeoplasmsIntestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmDigestive System DiseaseGastrointestinal DiseaseColonic DiseasesIntestinal Disease
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