Treatment Trials

4 Clinical Trials for Various Conditions

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COMPLETED
Family Caregivers in Underserved Populations Providing Complex Cancer Care
Description

This clinical trial develops and tests a model of family caregiver education focused on the role of underserved family caregivers as providers of complex care in the home. Cancer patients have symptoms from their cancer or treatment and are then supported by family caregivers at home with tasks requiring technical skill. Family caregivers are often asked to provide complex care whether it involves decisions about managing symptoms or providing technical care for ports/pumps, tubes, or devices. Family caregivers often are not given enough information on how to provide care for patients at home needing complex care. The results from this study may help researchers refine and improve the intervention for caregivers through future research for caregivers on a much larger scale.

COMPLETED
Characterizing Chemo-Radiotherapy Treatment-Related Cardiac Changes
Description

This trial studies cardiac changes after radiation or chemo-radiation for the treatment of lung or esophageal cancer that has not spread to other places in the body (non-metastatic) or has not come back (non-recurrent). Continuous cardiac monitoring with an implanted device may help to identify cardiac changes that would remain unnoticed, and facilitate the treatment of these early cardiac changes as part of standard care.

Conditions
Clinical Stage 0 Esophageal Adenocarcinoma AJCC V8Clinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC V8Clinical Stage I Esophageal Adenocarcinoma AJCC V8Clinical Stage I Esophageal Squamous Cell Carcinoma AJCC V8Clinical Stage II Esophageal Adenocarcinoma AJCC V8Clinical Stage II Esophageal Squamous Cell Carcinoma AJCC V8Clinical Stage IIA Esophageal Adenocarcinoma AJCC V8Clinical Stage IIB Esophageal Adenocarcinoma AJCC V8Clinical Stage III Esophageal Adenocarcinoma AJCC V8Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC V8Localized Esophageal CarcinomaLocalized Lung CarcinomaPathologic Stage 0 Esophageal Adenocarcinoma AJCC V8Pathologic Stage 0 Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage I Esophageal Adenocarcinoma AJCC V8Pathologic Stage I Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IA Esophageal Adenocarcinoma AJCC V8Pathologic Stage IA Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IB Esophageal Adenocarcinoma AJCC V8Pathologic Stage IB Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IC Esophageal Adenocarcinoma AJCC V8Pathologic Stage II Esophageal Adenocarcinoma AJCC V8Pathologic Stage II Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IIA Esophageal Adenocarcinoma AJCC V8Pathologic Stage IIA Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IIB Esophageal Adenocarcinoma AJCC V8Pathologic Stage IIB Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage III Esophageal Adenocarcinoma AJCC V8Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IIIA Esophageal Adenocarcinoma AJCC V8Pathologic Stage IIIA Esophageal Squamous Cell Carcinoma AJCC V8Pathologic Stage IIIB Esophageal Adenocarcinoma AJCC V8Pathologic Stage IIIB Esophageal Squamous Cell Carcinoma AJCC V8Postneoadjuvant Therapy Stage I Esophageal Adenocarcinoma AJCC V8Postneoadjuvant Therapy Stage I Esophageal Squamous Cell Carcinoma AJCC V8Postneoadjuvant Therapy Stage II Esophageal Adenocarcinoma AJCC V8Postneoadjuvant Therapy Stage II Esophageal Squamous Cell Carcinoma AJCC V8Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC V8Postneoadjuvant Therapy Stage III Esophageal Squamous Cell Carcinoma AJCC V8Postneoadjuvant Therapy Stage IIIA Esophageal Adenocarcinoma AJCC V8Postneoadjuvant Therapy Stage IIIA Esophageal Squamous Cell Carcinoma AJCC V8Postneoadjuvant Therapy Stage IIIB Esophageal Adenocarcinoma AJCC V8Postneoadjuvant Therapy Stage IIIB Esophageal Squamous Cell Carcinoma AJCC V8Stage 0 Lung Cancer AJCC V8Stage I Lung Cancer AJCC V8Stage IA1 Lung Cancer AJCC V8Stage IA2 Lung Cancer AJCC V8Stage IA3 Lung Cancer AJCC V8Stage IB Lung Cancer AJCC V8Stage II Lung Cancer AJCC V8Stage IIA Lung Cancer AJCC V8Stage IIB Lung Cancer AJCC V8Stage III Lung Cancer AJCC V8Stage IIIA Lung Cancer AJCC V8Stage IIIB Lung Cancer AJCC V8Stage IIIC Lung Cancer AJCC V8
COMPLETED
Geriatric and Quality of Life Assessments in Older Patients With Non-metastatic or Metastatic Head and Neck or Lung Cancer Undergoing Surgery or Chemoradiation and Their Caregivers
Description

This trial studies comprehensive geriatric and quality of life assessments in older patients with head and neck or lung cancer that has or has not spread to other parts of the body who are undergoing standard surgery or chemoradiation, and their caregivers. Comprehensive geriatric assessment may improve the quality of life of patients with head and neck or lung cancer and their caregivers.

RECRUITING
Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer
Description

This trial studies the role of the gut microbiome and effectiveness of a fecal transplant on medication-induced gastrointestinal (GI) complications in patients with melanoma or genitourinary cancer. The gut microbiome (the bacteria and microorganisms that live in the digestive system) may affect whether or not someone develops colitis (inflammation of the intestines) during cancer treatment with immune-checkpoint inhibitor drugs. Studying samples of stool, blood, and tissue from patients with melanoma or genitourinary cancer may help doctors learn more about the effects of treatment on cells, and help doctors understand how well patients respond to treatment. Treatment with fecal transplantation may help to improve diarrhea and colitis symptoms.

Conditions
Clinical Stage 0 Cutaneous Melanoma AJCC v8Clinical Stage I Cutaneous Melanoma AJCC v8Clinical Stage IA Cutaneous Melanoma AJCC v8Clinical Stage IB Cutaneous Melanoma AJCC v8Clinical Stage II Cutaneous Melanoma AJCC v8Clinical Stage IIA Cutaneous Melanoma AJCC v8Clinical Stage IIB Cutaneous Melanoma AJCC v8Clinical Stage IIC Cutaneous Melanoma AJCC v8Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8ColitisLung Non-Small Cell CarcinomaMalignant Genitourinary System NeoplasmMalignant Solid NeoplasmPathologic Stage 0 Cutaneous Melanoma AJCC v8Pathologic Stage I Cutaneous Melanoma AJCC v8Pathologic Stage IA Cutaneous Melanoma AJCC v8Pathologic Stage IB Cutaneous Melanoma AJCC v8Pathologic Stage II Cutaneous Melanoma AJCC v8Pathologic Stage IIA Cutaneous Melanoma AJCC v8Pathologic Stage IIB Cutaneous Melanoma AJCC v8Pathologic Stage IIC Cutaneous Melanoma AJCC v8Pathologic Stage III Cutaneous Melanoma AJCC v8Pathologic Stage IIIA Cutaneous Melanoma AJCC v8Pathologic Stage IIIB Cutaneous Melanoma AJCC v8Pathologic Stage IIIC Cutaneous Melanoma AJCC v8Pathologic Stage IIID Cutaneous Melanoma AJCC v8Pathologic Stage IV Cutaneous Melanoma AJCC v8Stage 0 Lung Cancer AJCC v8Stage I Lung Cancer AJCC v8Stage IA1 Lung Cancer AJCC v8Stage IA2 Lung Cancer AJCC v8Stage IA3 Lung Cancer AJCC v8Stage IB Lung Cancer AJCC v8Stage II Lung Cancer AJCC v8Stage IIA Lung Cancer AJCC v8Stage IIB Lung Cancer AJCC v8Stage III Lung Cancer AJCC v8Stage IIIA Lung Cancer AJCC v8Stage IIIB Lung Cancer AJCC v8Stage IIIC Lung Cancer AJCC v8Stage IV Lung Cancer AJCC v8Stage IVA Lung Cancer AJCC v8Stage IVB Lung Cancer AJCC v8