Treatment Trials

2 Clinical Trials for Various Conditions

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      COMPLETED
      Neoadjuvant and Adjuvant Checkpoint Blockade
      Description

      This randomized phase II trial studies how well nivolumab with or without ipilimumab or relatlimab before surgery works in treating patients with stage IIIB-IV melanoma that can be removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, and relatlimab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving nivolumab alone or in combination with ipilimumab or relatlimab before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.

      Conditions
      Cutaneous MelanomaMucosal MelanomaOcular MelanomaStage III Acral Lentiginous Melanoma AJCC v7Stage IIIB Cutaneous Melanoma AJCC v7Stage IIIB Uveal Melanoma AJCC v7Stage IIIC Cutaneous Melanoma AJCC v7Stage IIIC Uveal Melanoma AJCC v7Stage IV Acral Lentiginous Melanoma AJCC v6 and v7Stage IV Cutaneous Melanoma AJCC v6 and v7Stage IV Uveal Melanoma AJCC v7
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      ACTIVE_NOT_RECRUITING
      Dinaciclib in Treating Patients With Stage IV Melanoma
      Description

      This phase II trial is studying the side effects and how well dinaciclib works in treating patients with stage IV melanoma. Dinaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

      Conditions
      Acral Lentiginous MelanomaCutaneous Nodular MelanomaLentigo Maligna MelanomaLow-CSD MelanomaMucosal MelanomaRecurrent MelanomaStage IV Cutaneous Melanoma AJCC v6 and v7
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