Treatment Trials

4 Clinical Trials for Various Conditions

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      ACTIVE_NOT_RECRUITING
      Spectrum of Peripheral and Autonomic Neuropathies in Patients With aTTRwt Amyloidosis and Response to Patisiran Therapy
      Description

      To evaluate the efficacy and safety of patisiran in patients with wtATTR amyloidosis and symptomatic polyneuropathy by evaluating the effect on neurologic impairment and quality of life.

      Conditions
      PolyneuropathiesWild Type ATTR AmyloidosisWild-Type Transthyretin-Related (ATTR)AmyloidosisWild-Type Transthyretin Cardiac AmyloidosisTransthyretin Amyloidosis
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      ENROLLING_BY_INVITATION
      A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
      Description

      The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.

      Conditions
      Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
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      RECRUITING
      MAGNITUDE: a Phase 3 Study of NTLA-2001 in Participants with Transthyretin Amyloidosis with Cardiomyopathy (ATTR-CM)
      Description

      To evaluate the efficacy and safety of a single dose of NTLA-2001 compared to placebo in participants with ATTR-CM.

      Conditions
      Transthyretin Amyloidosis (ATTR) with Cardiomyopathy
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      ACTIVE_NOT_RECRUITING
      HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
      Description

      This study will evaluate the efficacy and safety of vutrisiran 25 mg administered subcutaneously (SC) once every 3 months (q3M) compared to placebo in patients with ATTR amyloidosis with cardiomyopathy.

      Conditions
      Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
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