RECRUITING

Evaluation of Patients With Non-obstructive Coronary Arteries

Description

Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment. When these patients undergo a comprehensive evaluation at the time of invasive coronary angiography, occult coronary abnormalities are frequently found. We hope to learn the overall prevalence and presentation of these occult coronary abnormalities and its long term outcome in this patient population.

Conditions

Chest PainIschemia
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Related Conditions:

Chest PainIschemia

Study Overview

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Study Details

Study overview

Patients with angina and non-obstructive CAD are common within clinical practice, but remain a challenge with regard to diagnosis and treatment. When these patients undergo a comprehensive evaluation at the time of invasive coronary angiography, occult coronary abnormalities are frequently found. We hope to learn the overall prevalence and presentation of these occult coronary abnormalities and its long term outcome in this patient population.

Evaluation of Patients With Angina in the Absence of Obstructive Coronary Artery Disease

Evaluation of Patients With Non-obstructive Coronary Arteries

Condition
Chest Pain
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University School of Medicine, Stanford, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patient referred for elective coronary angiography because of a reasonable clinical suspicion of coronary ischemia.
  • 2. Presence of angina or an anginal equivalent (including chest, back, shoulder, arm, neck, jaw discomfort, or shortness of breath brought on by physical exertion, emotional stress, or certain times of day/month).
  • 1. Asymptomatic (such as a pre-op cath)
  • 2. Status-post heart transplant
  • 3. Age \<18
  • 4. Renal insufficiency (creatinine \>1.5)
  • 5. Presence of an acute coronary syndrome (STEMI or NSTEMI), Tako-tsubo, an abnormal ejection fraction (EF\<55%), cardiogenic shock, or recent VT/VF
  • 6. Presence of another likely explanation of chest pain, such as pulmonary hypertension or aortic stenosis
  • 7. History of adverse reaction to any of the medications being used (acetylcholine, nitroglycerin, adenosine, or heparin)
  • 8. Currently taking vasoactive medication (such as nitroglycerin)
  • 9. Inability to provide an informed consent, including an inability to speak, read, or understand English, Spanish, Chinese, Farsi, Japanese, Korean, Russian, or Vietnamese
  • 10. A hearing impairment that won't allow for a typical verbal conversation or a visual impairment that won't allow for reading of the written consent
  • 11. Participation in another study (with the exception of the Stanford Gene-PAD study)
  • 12. A potentially vulnerable subject (including minors, pregnant women, economically and educationally disadvantaged, decisionally impaired, and homeless people)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Jennifer A Tremmel, MD, MS, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2047-06