RECRUITING

Childhood Cancer Survivor Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

Official Title

Childhood Cancer Survivor Study

Quick Facts

Study Start:1995-01-05
Study Completion:2026-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01120353

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:Not specified
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.
  2. * Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
  3. * English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
  1. * Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
  2. * Non-English speaking or residence outside the US or Canada.
  3. * For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.

Contacts and Locations

Study Contact

Gregory T. Armstrong, MD, MSCE
CONTACT
1-866-278-5833
referralinfo@stjude.org

Principal Investigator

Gregory T. Armstrong, MD, MSCE
PRINCIPAL_INVESTIGATOR
St. Jude Children's Research Hospital

Study Locations (Sites)

University of Alabama at Birmingham/Children's of Alabama
Birmingham, Alabama, 35294
United States
City of Hope National Medical Center
Duarte, California, 91010
United States
Children's Hospital Los Angeles
Los Angeles, California, 90027
United States
University of California-Los Angeles
Los Angeles, California, 90095
United States
Children's Hospital of Orange County
Orange, California, 92868
United States
University of California-San Francisco
San Francisco, California, 94143
United States
Stanford University School of Medicine
Stanford, California, 94305
United States
Children's Hospital Colorado
Aurora, Colorado, 80045
United States
Children's National Medical Center
Washington, District of Columbia, 20010
United States
Emory University/Children's Health Care of Atlanta
Atlanta, Georgia, 30322
United States
Ana & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611-2605
United States
University of Chicago
Chicago, Illinois, 60637
United States
Indiana University/Riley Hospital for Children
Indianapolis, Indiana, 46202
United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
United States
University of Michigan/Mott Children's Hospital
Ann Arbor, Michigan, 48109
United States
Children's Hospitals & Clinics of Minnesota
Minneapolis, Minnesota, 55404
United States
University of Minnesota
Minneapolis, Minnesota, 55455
United States
Mayo Clinic
Rochester, Minnesota, 55905
United States
St. Louis Children's Hospital/The Washington University
Saint Louis, Missouri, 63130
United States
Roswell Park Cancer Institute
Buffalo, New York, 14263
United States
Memorial-Sloan Kettering Cancer Center
New York, New York, 10065
United States
Nationwide Children's Hospital
Columbus, Ohio, 43205
United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104
United States
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States
St. Jude Children's Research Hospital
Memphis, Tennessee, 38105
United States
University of Texas Southwestern Medical Center
Dallas, Texas, 75390
United States
Cook Children's Medical Center
Fort Worth, Texas, 76104
United States
M.D. Anderson Cancer Center
Houston, Texas, 77030
United States
Texas Children's Hospital
Houston, Texas, 77030
United States
Seattle Children's Hospital
Seattle, Washington, 98105
United States

Collaborators and Investigators

Sponsor: St. Jude Children's Research Hospital

  • Gregory T. Armstrong, MD, MSCE, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date1995-01-05
Study Completion Date2026-11

Study Record Updates

Study Start Date1995-01-05
Study Completion Date2026-11

Terms related to this study

Keywords Provided by Researchers

  • Childhood cancer
  • Young Children
  • Adults

Additional Relevant MeSH Terms

  • Cancer