Childhood Cancer Survivor Study

Description

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

Conditions

Cancer

Study Overview

Study Details

Study overview

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

Childhood Cancer Survivor Study

Childhood Cancer Survivor Study

Condition
Cancer
Intervention / Treatment

-

Contacts and Locations

Birmingham

University of Alabama at Birmingham/Children's of Alabama, Birmingham, Alabama, United States, 35294

Duarte

City of Hope National Medical Center, Duarte, California, United States, 91010

Los Angeles

Children's Hospital Los Angeles, Los Angeles, California, United States, 90027

Los Angeles

University of California-Los Angeles, Los Angeles, California, United States, 90095

Orange

Children's Hospital of Orange County, Orange, California, United States, 92868

San Francisco

University of California-San Francisco, San Francisco, California, United States, 94143

Stanford

Stanford University School of Medicine, Stanford, California, United States, 94305

Aurora

Children's Hospital Colorado, Aurora, Colorado, United States, 80045

Washington

Children's National Medical Center, Washington, District of Columbia, United States, 20010

Atlanta

Emory University/Children's Health Care of Atlanta, Atlanta, Georgia, United States, 30322

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.
  • * Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
  • * English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
  • * Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
  • * Non-English speaking or residence outside the US or Canada.
  • * For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

St. Jude Children's Research Hospital,

Gregory T. Armstrong, MD, MSCE, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital

Study Record Dates

2026-11