RECRUITING

Genes and Environment in Multiple Sclerosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Official Title

Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility

Quick Facts

Study Start:2017-10-01
Study Completion:2040-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01353547

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * First Degree Relatives of Patients with MS, or
  2. * Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
  3. * Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
  4. * Live in the United States
  1. * Does not match any of the inclusion criteria

Contacts and Locations

Study Contact

Fatoumata B. Diallo, BS
CONTACT
212-304-1548
fd2292@cumc.columbia.edu
Kaho Onomichi
CONTACT
212-305-9155
ko2418@cumc.columbia.edu

Principal Investigator

Zongqi Xia, MD, PhD
STUDY_DIRECTOR
University of Pittsburgh

Study Locations (Sites)

National Institute of Neurological Disorders and Stroke
Bethesda, Maryland, 15213
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Brigham and Women's Hospital
Boston, Massachusetts, 02115
United States
Columbia University Irving Center
New York, New York, 10032
United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Columbia University

  • Zongqi Xia, MD, PhD, STUDY_DIRECTOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-10-01
Study Completion Date2040-10

Study Record Updates

Study Start Date2017-10-01
Study Completion Date2040-10

Terms related to this study

Keywords Provided by Researchers

  • genomic analysis
  • online surveys
  • biological specimen collection

Additional Relevant MeSH Terms

  • Multiple Sclerosis