Genes and Environment in Multiple Sclerosis

Description

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Conditions

Multiple Sclerosis

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Study Overview

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Study Details

Study overview

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility

Genes and Environment in Multiple Sclerosis

Condition
Multiple Sclerosis
Intervention / Treatment

-

Contacts and Locations

Bethesda

National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States, 15213

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115

New York

Columbia University Irving Center, New York, New York, United States, 10032

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * First Degree Relatives of Patients with MS, or
  • * Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or
  • * Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS
  • * Live in the United States
  • * Does not match any of the inclusion criteria

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Columbia University,

Zongqi Xia, MD, PhD, STUDY_DIRECTOR, University of Pittsburgh

Study Record Dates

2040-10