RECRUITING

Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to see if giving reduced intensity chemotherapy, haploidentical bone marrow, post-transplant cyclophosphamide and shortened duration tacrolimus is safe and feasible for patients with very high-risk solid tumors.

Official Title

A Phase II Trial of Reduced Intensity Conditioning and Partially HLA-mismatched (HLA-haploidentical) Related Donor Bone Marrow Transplantation for High-risk Solid Tumors

Quick Facts

Study Start:2013-03-27
Study Completion:2030-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01804634

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:1 Year to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Heather Symons, MD, MHS
CONTACT
410-502-4997
hsymons2@jhmi.edu
Jasmine Brooks, BA
CONTACT
667-306-8335
jbrook54@jhmi.edu

Principal Investigator

Heather Symons, MD, MHS
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Johns Hopkins All Children's Hospital
Saint Petersburg, Florida, 33701
United States
The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231
United States
Albert Einstein College of Medicine, Children's Hospital at Montefiore
Bronx, New York, 10467
United States
New York Medical Center/ Maria Fareri Children's Hospital
Valhalla, New York, 10595
United States

Collaborators and Investigators

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

  • Heather Symons, MD, MHS, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2013-03-27
Study Completion Date2030-01

Study Record Updates

Study Start Date2013-03-27
Study Completion Date2030-01

Terms related to this study

Keywords Provided by Researchers

  • Solid Tumors
  • Neuroblastoma
  • Osteosarcoma
  • Ewing Sarcoma
  • Rhabdomyosarcoma
  • Hepatoblastoma
  • Desmoplastic Round Cell Tumor

Additional Relevant MeSH Terms

  • Refractory and/or Relapsed Metastatic Solid Tumors