Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

Description

The purpose of this study is to see if giving reduced intensity chemotherapy, haploidentical bone marrow, post-transplant cyclophosphamide and shortened duration tacrolimus is safe and feasible for patients with very high-risk solid tumors.

Conditions

Refractory and/or Relapsed Metastatic Solid Tumors

Study Overview

Study Details

Study overview

The purpose of this study is to see if giving reduced intensity chemotherapy, haploidentical bone marrow, post-transplant cyclophosphamide and shortened duration tacrolimus is safe and feasible for patients with very high-risk solid tumors.

A Phase II Trial of Reduced Intensity Conditioning and Partially HLA-mismatched (HLA-haploidentical) Related Donor Bone Marrow Transplantation for High-risk Solid Tumors

Reduced Intensity Haploidentical BMT for High Risk Solid Tumors

Condition
Refractory and/or Relapsed Metastatic Solid Tumors
Intervention / Treatment

-

Contacts and Locations

Saint Petersburg

Johns Hopkins All Children's Hospital, Saint Petersburg, Florida, United States, 33701

Baltimore

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States, 21231

Bronx

Albert Einstein College of Medicine, Children's Hospital at Montefiore, Bronx, New York, United States, 10467

Valhalla

New York Medical Center/ Maria Fareri Children's Hospital, Valhalla, New York, United States, 10595

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    1 Year to 50 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins,

    Heather Symons, MD, MHS, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

    Study Record Dates

    2030-01