RECRUITING

Allograft Dysfunction in Heart Transplant

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Conditions

Heart Transplant Failure and Rejectionheart transplantacute graft rejectionchronic graft rejection

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

Official Title

Defining Mechanisms for Cardiac Allograft Dysfunction to Improve Allograft Longevity and Survival in Heart-Transplant Patients

Quick Facts

Study Start:2019-10-01
Study Completion:2024-12-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03102125

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age greater than or equal to 18 years old.
  2. * At least three months status post heart transplantation.
  1. * Biopsy proven acute rejection episode in the past 3 months.
  2. * Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.
  3. * Uncontrolled obstructive ventilatory disease including asthma and COPD.
  4. * History of generalized tonic-clonic seizures.
  5. * Second or third degree AV nodal block.
  6. * Sinus node dysfunction.
  7. * Contraindications to MRI including cardiovascular implantable electronic devices.
  8. * Renal dysfunction with an estimated GFR less than 30 mL/min/1.73m2.
  9. * Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.
  10. * Systolic blood pressure greater than 180 or less than 85 mmHg.
  11. * Diastolic blood pressure greater than 120 or less than 40 mmHg.
  12. * Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.

Contacts and Locations

Study Contact

Paul Kim, MD
CONTACT
8582460638
pjk017@ucsd.edu

Principal Investigator

Paul Kim, MD
PRINCIPAL_INVESTIGATOR
UC San Diego

Study Locations (Sites)

UC San Diego
La Jolla, California, 92037
United States

Collaborators and Investigators

Sponsor: Paul Kim

  • Paul Kim, MD, PRINCIPAL_INVESTIGATOR, UC San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-10-01
Study Completion Date2024-12-02

Study Record Updates

Study Start Date2019-10-01
Study Completion Date2024-12-02

Terms related to this study

Keywords Provided by Researchers

  • heart transplant
  • acute graft rejection
  • chronic graft rejection

Additional Relevant MeSH Terms

  • Heart Transplant Failure and Rejection