Allograft Dysfunction in Heart Transplant

Description

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

Conditions

Heart Transplant Failure and Rejection

Talk to us

Study Overview

On this page

Study Details

Study overview

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

Defining Mechanisms for Cardiac Allograft Dysfunction to Improve Allograft Longevity and Survival in Heart-Transplant Patients

Allograft Dysfunction in Heart Transplant

Condition
Heart Transplant Failure and Rejection
Intervention / Treatment

-

Contacts and Locations

La Jolla

UC San Diego, La Jolla, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age greater than or equal to 18 years old.
  • * At least three months status post heart transplantation.
  • * Biopsy proven acute rejection episode in the past 3 months.
  • * Patients with symptoms or signs of acute myocardial ischemia or recent acute coronary syndrome in the past 3 months.
  • * Uncontrolled obstructive ventilatory disease including asthma and COPD.
  • * History of generalized tonic-clonic seizures.
  • * Second or third degree AV nodal block.
  • * Sinus node dysfunction.
  • * Contraindications to MRI including cardiovascular implantable electronic devices.
  • * Renal dysfunction with an estimated GFR less than 30 mL/min/1.73m2.
  • * Prior adverse reaction to either regadenoson or gadolinium contrast. Prior adverse reaction to adenosine or dipyridamole will be assessed on a case-by-case basis.
  • * Systolic blood pressure greater than 180 or less than 85 mmHg.
  • * Diastolic blood pressure greater than 120 or less than 40 mmHg.
  • * Resting heart rate greater than 120 or less than 45 beats per minute. - Severe claustrophobia.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Paul Kim,

Paul Kim, MD, PRINCIPAL_INVESTIGATOR, UC San Diego

Study Record Dates

2024-12-02