RECRUITING

Modulating Movement Intention Via Cortical Stimulation

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Conditions

SeizuresSeizure DisorderPsychogenic Movement DisorderElectroencephalographyMagnetoencephalographyTranscranial Magnetic Stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

Official Title

Modulating Movement Intention Via Cortical Stimulation in Healthy Subjects and Patients With Psychogenic Movement Disorders and Non-epileptic Seizures

Quick Facts

Study Start:2017-07-20
Study Completion:2025-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03233399

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Fluent in English
  2. * Diagnosis of PMD/PNES confirmed by a neurologist with expertise in movement disorders.
  3. * Per the treating neurologist, subject is unlikely to require treatment and/or dosage changes for 3-6 months following screening
  1. * Any history of a significant neurological disorder, which may interfere with the interpretation of study data, as determined by the PI
  2. * Chronic or progressive medical condition
  3. * Any history of traumatic brain injury or significant head trauma
  4. * Currently meets criteria for substance abuse or dependence
  5. * History of any psychotic disorder or other psychiatric condition which may interfere with data interpretation
  6. * Pregnancy
  7. * Metal or devices in the head, including neurostimulators or metal foreign bodies
  8. * Any other implanted metal device, including pacemaker, spinal cord stimulator, VNS.
  9. * Any other ferromagnetic substance in the body that may increase study risk (including dental prosthetics, etc.).
  10. * Taking tricyclic antidepressant or antiepileptic medications or CNS active drugs under "strong potential hazard" list in Rossi et al., 2009
  11. * Current diagnosis of any inflammatory or autoimmune disorder within last 6 months
  12. * Any history of traumatic brain injury or significant head trauma
  13. * Diagnosis of organic seizure disorder, including febrile seizures and tonic-clonic seizures;
  14. * Neurological disorder other than PMD and PNES including stroke, fainting spells or syncope of unknown cause(s);
  15. * Major or unstable medical illness, especially any current diagnosis of inflammatory or autoimmune disorders within last 6 months
  16. * Metal or devices in the head, including neurostimulators or metal foreign bodies
  17. * Taking tricyclic antidepressant medications or CNS active drugs under "strong potential hazard" list in Rossi et al., 2009;
  18. * Diagnosis of dementia, or Montreal Cognitive Assessment (MoCA) ≤24;
  19. * Recurrent visual hallucinations, within the past 6 months;
  20. * History of significant uncontrollable movements of the head;
  21. * Any clinically significant abnormality on vital signs

Contacts and Locations

Study Contact

Nalini Jeet
CONTACT
(212) 263-0228
Nalini.Jeet@nyulangone.org

Principal Investigator

Biyu He, MD
PRINCIPAL_INVESTIGATOR
NYU Langone Health

Study Locations (Sites)

New York University School of Medicine
New York, New York, 10016
United States

Collaborators and Investigators

Sponsor: NYU Langone Health

  • Biyu He, MD, PRINCIPAL_INVESTIGATOR, NYU Langone Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2017-07-20
Study Completion Date2025-05

Study Record Updates

Study Start Date2017-07-20
Study Completion Date2025-05

Terms related to this study

Keywords Provided by Researchers

  • Electroencephalography
  • Magnetoencephalography
  • Transcranial Magnetic Stimulation

Additional Relevant MeSH Terms

  • Seizures
  • Seizure Disorder
  • Psychogenic Movement Disorder