Modulating Movement Intention Via Cortical Stimulation

Description

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

Conditions

Seizures, Seizure Disorder, Psychogenic Movement Disorder

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Study Overview

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Study Details

Study overview

The purpose of this protocol is to learn about movement intention and volition. To improve such knowledge, investigators will conduct sub-studies using multiple non-invasive methodologies. These results could provide preliminary data for subsequent studies evaluating local and global efficacy of plasticity-inducing treatments for PMD symptoms.

Modulating Movement Intention Via Cortical Stimulation in Healthy Subjects and Patients With Psychogenic Movement Disorders and Non-epileptic Seizures

Modulating Movement Intention Via Cortical Stimulation

Condition
Seizures
Intervention / Treatment

-

Contacts and Locations

New York

New York University School of Medicine, New York, New York, United States, 10016

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Fluent in English
  • * Diagnosis of PMD/PNES confirmed by a neurologist with expertise in movement disorders.
  • * Per the treating neurologist, subject is unlikely to require treatment and/or dosage changes for 3-6 months following screening
  • * Any history of a significant neurological disorder, which may interfere with the interpretation of study data, as determined by the PI
  • * Chronic or progressive medical condition
  • * Any history of traumatic brain injury or significant head trauma
  • * Currently meets criteria for substance abuse or dependence
  • * History of any psychotic disorder or other psychiatric condition which may interfere with data interpretation
  • * Pregnancy
  • * Metal or devices in the head, including neurostimulators or metal foreign bodies
  • * Any other implanted metal device, including pacemaker, spinal cord stimulator, VNS.
  • * Any other ferromagnetic substance in the body that may increase study risk (including dental prosthetics, etc.).
  • * Taking tricyclic antidepressant or antiepileptic medications or CNS active drugs under "strong potential hazard" list in Rossi et al., 2009
  • * Current diagnosis of any inflammatory or autoimmune disorder within last 6 months
  • * Any history of traumatic brain injury or significant head trauma
  • * Diagnosis of organic seizure disorder, including febrile seizures and tonic-clonic seizures;
  • * Neurological disorder other than PMD and PNES including stroke, fainting spells or syncope of unknown cause(s);
  • * Major or unstable medical illness, especially any current diagnosis of inflammatory or autoimmune disorders within last 6 months
  • * Metal or devices in the head, including neurostimulators or metal foreign bodies
  • * Taking tricyclic antidepressant medications or CNS active drugs under "strong potential hazard" list in Rossi et al., 2009;
  • * Diagnosis of dementia, or Montreal Cognitive Assessment (MoCA) ≤24;
  • * Recurrent visual hallucinations, within the past 6 months;
  • * History of significant uncontrollable movements of the head;
  • * Any clinically significant abnormality on vital signs

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

NYU Langone Health,

Biyu He, MD, PRINCIPAL_INVESTIGATOR, NYU Langone Health

Study Record Dates

2025-05