RECRUITING

Use of Sensory Substitution to Improve Arm Control After Stroke

Conditions

Stroke Proprioceptive Disorders proprioception sensory substitution

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Supplementing or augmenting sensory information to those who have lost proprioception after stroke could help improve functional control of the arm. Thirty subjects will be recruited to a single site to evaluate the ability of supplemental kinesthetic feedback (a form of vibrotactile stimulation) to improve motor function. Participants will be tested in performing reaching movements as well as more functional tasks such as simulated drinking from a glass

Official Title

Augmenting Kinesthetic Feedback to Improve Hemiparetic Arm Control After Stroke

Quick Facts

Study Start:2023-07-17

Study Completion:2025-05-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT03298243

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* stroke survivors who can perform our stabilization and grip modulation tasks and who * had a single ischemic or hemorrhagic stroke of the middle cerebral artery (MCA) in the chronic state of recovery (\> 6 months post-stroke). * ability to give informed consent and be able to follow two-stage instructions. * mild-to-moderate motor impairment as assessed using the upper extremity (UE) portion of the Fugl-Meyer Motor Assessment (FM); i.e., UE-FM score between 28 and 50 (inclusive) out of a possible 66. * proprioceptive deficit at the elbow in the more involved (contralesional) arm. * preserved tactile sensation in either the ipsilesional arm and/or thigh. * a minimal active wrist extension of 5°.	* Inability of subjects to give informed consent or follow two-stage instructions. * subjects with a bleeding disorder. * subjects with fixed contractures or a history of tendon transfer in the involved limb. * subjects with a diagnosis of myasthenia gravis, amyotrophic lateral sclerosis or any disease that might interfere with neuromuscular function. * subjects who are currently using or under the influence of aminoglycoside antibiotics, curare-like agents, or other agents that may interfere with neuromuscular function. * subjects with a history of epilepsy. * history of other psychiatric co-morbidities (e.g. schizophrenia). * malignant or benign intra-axial neoplasms. * concurrent illness limiting the capacity to conform to study requirements. * Cardiac pacemaker, cardiac arrhythmia or history of significant cardiovascular or respiratory compromise. * subjects with profound atrophy or excessive weakness of muscles in the target area(s) of testing. * subjects with a systemic infection.

Inclusion Criteria

Exclusion Criteria

* stroke survivors who can perform our stabilization and grip modulation tasks and who
* had a single ischemic or hemorrhagic stroke of the middle cerebral artery (MCA) in the chronic state of recovery (\> 6 months post-stroke).
* ability to give informed consent and be able to follow two-stage instructions.
* mild-to-moderate motor impairment as assessed using the upper extremity (UE) portion of the Fugl-Meyer Motor Assessment (FM); i.e., UE-FM score between 28 and 50 (inclusive) out of a possible 66.
* proprioceptive deficit at the elbow in the more involved (contralesional) arm.
* preserved tactile sensation in either the ipsilesional arm and/or thigh.
* a minimal active wrist extension of 5°.

* Inability of subjects to give informed consent or follow two-stage instructions.
* subjects with a bleeding disorder.
* subjects with fixed contractures or a history of tendon transfer in the involved limb.
* subjects with a diagnosis of myasthenia gravis, amyotrophic lateral sclerosis or any disease that might interfere with neuromuscular function.
* subjects who are currently using or under the influence of aminoglycoside antibiotics, curare-like agents, or other agents that may interfere with neuromuscular function.
* subjects with a history of epilepsy.
* history of other psychiatric co-morbidities (e.g. schizophrenia).
* malignant or benign intra-axial neoplasms.
* concurrent illness limiting the capacity to conform to study requirements.
* Cardiac pacemaker, cardiac arrhythmia or history of significant cardiovascular or respiratory compromise.
* subjects with profound atrophy or excessive weakness of muscles in the target area(s) of testing.
* subjects with a systemic infection.

Contacts and Locations

Study Contact

Robert A Scheidt, PhD

CONTACT

(414)288-6124

robert.scheidt@marquette.edu

Kimberly D Bassindale, DPT

CONTACT

(414)288-6184

kimberly.bassindale@marquette.edu

Principal Investigator

Robert A Scheidt, PhD

PRINCIPAL_INVESTIGATOR

Marquette University

Study Locations (Sites)

Marquette University

Milwaukee, Wisconsin, 53233

United States

Collaborators and Investigators

Sponsor: Marquette University

Robert A Scheidt, PhD, PRINCIPAL_INVESTIGATOR, Marquette University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-17

Study Completion Date2025-05-31

Study Record Updates

Study Start Date2023-07-17

Study Completion Date2025-05-31

Terms related to this study

Keywords Provided by Researchers

stroke
proprioception
sensory substitution

Additional Relevant MeSH Terms

Stroke
Proprioceptive Disorders