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Early Childhood Obesity Programming by Intrauterine Growth Restriction

Description

The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.

Conditions

Childhood ObesityEpigenetics
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Related Conditions:

Childhood ObesityEpigenetics

Study Overview

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Study Details

Study overview

The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.

Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

Early Childhood Obesity Programming by Intrauterine Growth Restriction

Condition
Childhood Obesity
Intervention / Treatment

-

Contacts and Locations

Bronx

Jack D. Weiler Hospital, Bronx, New York, United States, 10461

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy singleton term IUGR and AGA infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center.
  • * Multiple gestation, maternal depression, maternal renal disease, infants in extremis, Apgar score \<7 at 5 min and umbilical artery pH ≤7.25, chromosomal/ congenital abnormalities, congenital infections and inborn errors of metabolism. We will also exclude infants born to mothers with a history of maternal smoking in the 2nd and 3rd trimester of pregnancy and maternal gestational diabetes/T2D.

Ages Eligible for Study

1 Hour to 24 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Montefiore Medical Center,

Mamta Fuloria, MD, PRINCIPAL_INVESTIGATOR, Montefiore Medical Center/Albert Einstein College of Medicine

Study Record Dates

2028-03