RECRUITING

Early Childhood Obesity Programming by Intrauterine Growth Restriction

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The molecular mechanisms underlying developmental programming of childhood obesity remain poorly understood. Here, the investigators address major questions about early childhood obesity programming by studying CD3+ T-cells from intrauterine growth restricted (IUGR) newborns who have an increased risk for obesity and other metabolic disorders in adult life.

Official Title

Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

Quick Facts

Study Start:2018-09-01

Study Completion:2028-03

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT03402139

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:1 Hour to 24 Months

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:CHILD

Inclusion Criteria	Exclusion Criteria
* Healthy singleton term IUGR and AGA infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center.	* Multiple gestation, maternal depression, maternal renal disease, infants in extremis, Apgar score \<7 at 5 min and umbilical artery pH ≤7.25, chromosomal/ congenital abnormalities, congenital infections and inborn errors of metabolism. We will also exclude infants born to mothers with a history of maternal smoking in the 2nd and 3rd trimester of pregnancy and maternal gestational diabetes/T2D.

Inclusion Criteria

Exclusion Criteria

* Healthy singleton term IUGR and AGA infants whose mothers are followed by the Obstetric Department of Montefiore Medical Center and who deliver at the Weiler Division of Montefiore Medical Center.

* Multiple gestation, maternal depression, maternal renal disease, infants in extremis, Apgar score \<7 at 5 min and umbilical artery pH ≤7.25, chromosomal/ congenital abnormalities, congenital infections and inborn errors of metabolism. We will also exclude infants born to mothers with a history of maternal smoking in the 2nd and 3rd trimester of pregnancy and maternal gestational diabetes/T2D.

Contacts and Locations

Study Contact

Mamta Fuloria, MD

CONTACT

718-904-4105

mfuloria@montefiore.org

Principal Investigator

Mamta Fuloria, MD

PRINCIPAL_INVESTIGATOR

Montefiore Medical Center/Albert Einstein College of Medicine

Study Locations (Sites)

Jack D. Weiler Hospital

Bronx, New York, 10461

United States

Collaborators and Investigators

Sponsor: Montefiore Medical Center

Mamta Fuloria, MD, PRINCIPAL_INVESTIGATOR, Montefiore Medical Center/Albert Einstein College of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-09-01

Study Completion Date2028-03

Study Record Updates

Study Start Date2018-09-01

Study Completion Date2028-03

Terms related to this study

Additional Relevant MeSH Terms

Childhood Obesity
Epigenetics