RECRUITING

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Conditions

Acute Stroke remote limb ischemic conditioning large vessel occlusion helicopter transport

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.

Official Title

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Quick Facts

Study Start:2020-06-01

Study Completion:2025-04-01

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT03481205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Age ≥18 and ≤ 80 years 2. Suspected acute ischemic stroke with symptoms suggestive of large vessel occlusion (aphasia, agnosia, neglect, visual field cut, and gaze preference). 3. Patient screened for rtPA, and rtPA administered if eligible 4. Subject or legally authorized representative able to provide consent at the time of the assessment 5. NIHSS 6-20	1. Any intracranial hemorrhage (parenchymal, subarachnoid, subdural, epidural) on CT scan at the community hospital 2. History of upper or lower extremity ischemia, known subclavian, brachial artery, iliac or femoral artery stenosis, subclavian steal syndrome, any upper or lower extremity soft tissue, orthopedic or vascular injury, or mastectomy or other procedure that may contraindicate taking blood pressure or having a cuff on the arm or leg for the conditioning treatment 3. History of diabetes mellitus 4. Enrollment in another clinical trial 5. Patient incarcerated 6. Pregnancy. Patients ages 18-55 will need to have a negative urine or blood based pregnancy test. 7. Agitation deemed unsafe for ischemic preconditioning testing. 8. Arteriovenous fistula in upper limb

Inclusion Criteria

Exclusion Criteria

1. Age ≥18 and ≤ 80 years
2. Suspected acute ischemic stroke with symptoms suggestive of large vessel occlusion (aphasia, agnosia, neglect, visual field cut, and gaze preference).
3. Patient screened for rtPA, and rtPA administered if eligible
4. Subject or legally authorized representative able to provide consent at the time of the assessment
5. NIHSS 6-20

1. Any intracranial hemorrhage (parenchymal, subarachnoid, subdural, epidural) on CT scan at the community hospital
2. History of upper or lower extremity ischemia, known subclavian, brachial artery, iliac or femoral artery stenosis, subclavian steal syndrome, any upper or lower extremity soft tissue, orthopedic or vascular injury, or mastectomy or other procedure that may contraindicate taking blood pressure or having a cuff on the arm or leg for the conditioning treatment
3. History of diabetes mellitus
4. Enrollment in another clinical trial
5. Patient incarcerated
6. Pregnancy. Patients ages 18-55 will need to have a negative urine or blood based pregnancy test.
7. Agitation deemed unsafe for ischemic preconditioning testing.
8. Arteriovenous fistula in upper limb

Contacts and Locations

Study Contact

Amir Shaban, MD

CONTACT

3193568755

amir-shaban@uiowa.edu

Principal Investigator

Enrique Leira, MD

PRINCIPAL_INVESTIGATOR

University of Iowa Hospitals and Clinics- 200 Hawkins Dr, Iowa City, IA 52242

Study Locations (Sites)

University of Iowa

Iowa City, Iowa, 52242

United States

Collaborators and Investigators

Sponsor: Enrique Leira

Enrique Leira, MD, PRINCIPAL_INVESTIGATOR, University of Iowa Hospitals and Clinics- 200 Hawkins Dr, Iowa City, IA 52242

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-06-01

Study Completion Date2025-04-01

Study Record Updates

Study Start Date2020-06-01

Study Completion Date2025-04-01

Terms related to this study

Keywords Provided by Researchers

remote limb ischemic conditioning
large vessel occlusion
helicopter transport

Additional Relevant MeSH Terms

Acute Stroke