Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Description

The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.

Conditions

Acute Stroke

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Study Overview

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Study Details

Study overview

The purpose of this study is to demonstrate the feasibility of performing remote limb ischemic conditioning (RLIC) using the Doctormate device, a special blood pressure device used to perform RLIC, on patients with acute ischemic stroke due to large vessel occlusion being transported to a thrombectomy capable center by the helicopter.

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Ischemic Conditioning During Air tRansport Save penUmbral Tissue

Condition
Acute Stroke
Intervention / Treatment

-

Contacts and Locations

Iowa City

University of Iowa, Iowa City, Iowa, United States, 52242

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Age ≥18 and ≤ 80 years
  • 2. Suspected acute ischemic stroke with symptoms suggestive of large vessel occlusion (aphasia, agnosia, neglect, visual field cut, and gaze preference).
  • 3. Patient screened for rtPA, and rtPA administered if eligible
  • 4. Subject or legally authorized representative able to provide consent at the time of the assessment
  • 5. NIHSS 6-20
  • 1. Any intracranial hemorrhage (parenchymal, subarachnoid, subdural, epidural) on CT scan at the community hospital
  • 2. History of upper or lower extremity ischemia, known subclavian, brachial artery, iliac or femoral artery stenosis, subclavian steal syndrome, any upper or lower extremity soft tissue, orthopedic or vascular injury, or mastectomy or other procedure that may contraindicate taking blood pressure or having a cuff on the arm or leg for the conditioning treatment
  • 3. History of diabetes mellitus
  • 4. Enrollment in another clinical trial
  • 5. Patient incarcerated
  • 6. Pregnancy. Patients ages 18-55 will need to have a negative urine or blood based pregnancy test.
  • 7. Agitation deemed unsafe for ischemic preconditioning testing.
  • 8. Arteriovenous fistula in upper limb

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Enrique Leira,

Enrique Leira, MD, PRINCIPAL_INVESTIGATOR, University of Iowa Hospitals and Clinics- 200 Hawkins Dr, Iowa City, IA 52242

Study Record Dates

2025-04-01