RECRUITING

Longitudinal Early-onset Alzheimer's Disease Study Protocol

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Conditions

Early Onset Alzheimer DiseaseAlzheimer DiseaseMild Cognitive ImpairmentCognitively NormalAmyloidPlaquesNeuroimagingBiomarkersCognition DisorderDementiaTauEarly Onset Alzheimer's DiseaseAlzheimer's Disease

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EOnonAD) participants, and (3) cognitively normal (CN) control participants.

Official Title

Longitudinal Early-onset Alzheimer's Disease Study Protocol

Quick Facts

Study Start:2018-04-30
Study Completion:2025-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03507257

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 64 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

IU LEADS Team
CONTACT
317-963-7436
iuLEADS@iupui.edu

Principal Investigator

Liana Apostolova, MD
PRINCIPAL_INVESTIGATOR
Indiana University

Study Locations (Sites)

Banner Sun Health Research Institute
Sun City, Arizona, 85351
United States
University of California, Los Angeles
Los Angeles, California, 90095
United States
Stanford University
Palo Alto, California, 94304
United States
University of California, San Francisco
San Francisco, California, 94121
United States
Georgetown University
Washington, District of Columbia, 20057
United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, 32224
United States
Wien Center
Miami Beach, Florida, 33140
United States
Emory University
Atlanta, Georgia, 30322
United States
Northwestern University
Chicago, Illinois, 60611
United States
Indiana University
Indianapolis, Indiana, 47405
United States
Johns Hopkins University
Baltimore, Maryland, 21218
United States
Massachusetts General Hospital
Boston, Massachusetts, 02114
United States
Mayo Clinic, Rochester
Rochester, Minnesota, 55905
United States
Washington University, St. Louis
Saint Louis, Missouri, 63130
United States
Columbia University
New York, New York, 10032
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
Butler Hospital
Providence, Rhode Island, 02906
United States
Houston Methodist Hospital
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Indiana University

  • Liana Apostolova, MD, PRINCIPAL_INVESTIGATOR, Indiana University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-04-30
Study Completion Date2025-05-31

Study Record Updates

Study Start Date2018-04-30
Study Completion Date2025-05-31

Terms related to this study

Keywords Provided by Researchers

  • Cognitively Normal
  • Amyloid
  • Plaques
  • Neuroimaging
  • Biomarkers
  • Cognition Disorder
  • Dementia
  • Tau
  • Early Onset Alzheimer's Disease
  • Alzheimer's Disease
  • Mild Cognitive Impairment

Additional Relevant MeSH Terms

  • Early Onset Alzheimer Disease
  • Alzheimer Disease
  • Mild Cognitive Impairment