Longitudinal Early-onset Alzheimer's Disease Study Protocol

Description

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EOnonAD) participants, and (3) cognitively normal (CN) control participants.

Conditions

Early Onset Alzheimer Disease, Alzheimer Disease, Mild Cognitive Impairment

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Study Overview

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Study Details

Study overview

The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) is a non-randomized, natural history, non-treatment study designed to look at disease progression in individuals with early onset cognitive impairment. Clinical, cognitive, imaging, biomarker, and genetic characteristics will be assessed across three cohorts: (1) early onset Alzheimer's Disease (EOAD) participants, (2) early onset non-Alzheimer's Disease (EOnonAD) participants, and (3) cognitively normal (CN) control participants.

Longitudinal Early-onset Alzheimer's Disease Study Protocol

Longitudinal Early-onset Alzheimer's Disease Study Protocol

Condition
Early Onset Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Sun City

Banner Sun Health Research Institute, Sun City, Arizona, United States, 85351

Los Angeles

University of California, Los Angeles, Los Angeles, California, United States, 90095

Palo Alto

Stanford University, Palo Alto, California, United States, 94304

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94121

Washington

Georgetown University, Washington, District of Columbia, United States, 20057

Jacksonville

Mayo Clinic, Jacksonville, Jacksonville, Florida, United States, 32224

Miami Beach

Wien Center, Miami Beach, Florida, United States, 33140

Atlanta

Emory University, Atlanta, Georgia, United States, 30322

Chicago

Northwestern University, Chicago, Illinois, United States, 60611

Indianapolis

Indiana University, Indianapolis, Indiana, United States, 47405

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    40 Years to 64 Years

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    Yes

    Collaborators and Investigators

    Indiana University,

    Liana Apostolova, MD, PRINCIPAL_INVESTIGATOR, Indiana University

    Study Record Dates

    2025-05-31