COMPLETED

Functional Imaging Reserve in NeuroHIV

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to look at the brain's efficiency and ability to make up for deficits in the front of the brain to see if people living with HIV (PLWH) are still able to perform well on various cognitive tasks even though there are other underlying processes at work, like inflammation, that affect the brain in a negative way. Results of this study may provide insight into the pathophysiology of disease and may reveal arenas for future possible interventions in PLWH who have impaired neuropsychological performance.

Official Title

Functional Imaging Reserve in NeuroHIV

Quick Facts

Study Start:2018-11-20
Study Completion:2025-04-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT03596268

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 20 to 80 years old
  2. * documented HIV infection for at least 1 year or confirmed HIV - status
  3. * PLWH must be on stable cART regimen for at least 12 months with undetectable plasma HIV RNA (less than 50 copies per mL)
  4. * at least 9 years of education
  5. * able to provide informed consent
  6. * if female, a negative pregnancy test and not breast feeding
  7. * able to undergo an MRI scan
  1. * significant neurological disorders (e.g. stroke, head injury with loss of consciousness for more than 5 minutes, developmental learning disability)
  2. * active uncontrolled Axis I psychiatric disorder according to the DSM 5
  3. * current or history of substance use disorder (including, but not limited to amphetamines, cocaine, alcohol, opiates, and barbiturates)
  4. * prescribed blood thinners
  5. * allergic to lidocaine or similar anesthetic
  6. * history of any bleeding disorder
  7. * contraindication to MRI scanning (e.g. claustrophobia, pacemaker, etc.)
  8. * pregnant or breastfeeding

Contacts and Locations

Principal Investigator

Beau M Ances, MD, PhD
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine

Study Locations (Sites)

Washington University School of Medicine
St Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Beau M Ances, MD, PhD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-11-20
Study Completion Date2025-04-30

Study Record Updates

Study Start Date2018-11-20
Study Completion Date2025-04-30

Terms related to this study

Additional Relevant MeSH Terms

  • HIV