Functional Imaging Reserve in NeuroHIV

Description

The purpose of this research study is to look at the brain's efficiency and ability to make up for deficits in the front of the brain to see if people living with HIV (PLWH) are still able to perform well on various cognitive tasks even though there are other underlying processes at work, like inflammation, that affect the brain in a negative way. Results of this study may provide insight into the pathophysiology of disease and may reveal arenas for future possible interventions in PLWH who have impaired neuropsychological performance.

Conditions

HIV

Study Overview

Study Details

Study overview

The purpose of this research study is to look at the brain's efficiency and ability to make up for deficits in the front of the brain to see if people living with HIV (PLWH) are still able to perform well on various cognitive tasks even though there are other underlying processes at work, like inflammation, that affect the brain in a negative way. Results of this study may provide insight into the pathophysiology of disease and may reveal arenas for future possible interventions in PLWH who have impaired neuropsychological performance.

Functional Imaging Reserve in NeuroHIV

Functional Imaging Reserve in NeuroHIV

Condition
HIV
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University School of Medicine, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 20 to 80 years old
  • * documented HIV infection for at least 1 year or confirmed HIV - status
  • * PLWH must be on stable cART regimen for at least 12 months with undetectable plasma HIV RNA (less than 50 copies per mL)
  • * at least 9 years of education
  • * able to provide informed consent
  • * if female, a negative pregnancy test and not breast feeding
  • * able to undergo an MRI scan
  • * significant neurological disorders (e.g. stroke, head injury with loss of consciousness for more than 5 minutes, developmental learning disability)
  • * active uncontrolled Axis I psychiatric disorder according to the DSM 5
  • * current or history of substance use disorder (including, but not limited to amphetamines, cocaine, alcohol, opiates, and barbiturates)
  • * prescribed blood thinners
  • * allergic to lidocaine or similar anesthetic
  • * history of any bleeding disorder
  • * contraindication to MRI scanning (e.g. claustrophobia, pacemaker, etc.)
  • * pregnant or breastfeeding

Ages Eligible for Study

20 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Washington University School of Medicine,

Beau M Ances, MD, PhD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2025-07-31