RECRUITING

Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.

Official Title

A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Quick Facts

Study Start:2019-09-03
Study Completion:2026-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03681275

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients undergoing esophagectomy
  1. * Patients with more than mild pulmonary dysfunction
  2. * Patients with any neuromuscular disease that might compromise diaphragm function
  3. * Patients with abnormal liver or kidney function
  4. * Patients taking any immunosuppressant medication (including prednisone) or antifungal medications
  5. * History of tuberculosis
  6. * Weight loss of \>5% of body weight over previous 6 months
  7. * Pregnancy

Contacts and Locations

Study Contact

Cheyenne A Clinical Research Coordinator, B.S, M.S
CONTACT
3107201689
csadeghi@stanford.edu

Principal Investigator

Joseph Shrager, MD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford University Medical Center
Stanford, California, 94305
United States

Collaborators and Investigators

Sponsor: Stanford University

  • Joseph Shrager, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-09-03
Study Completion Date2026-11-30

Study Record Updates

Study Start Date2019-09-03
Study Completion Date2026-11-30

Terms related to this study

Keywords Provided by Researchers

  • Ventilator-induced Diaphragm Dysfunction

Additional Relevant MeSH Terms

  • Diaphragm Injury