Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Description

We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.

Conditions

Diaphragm Injury

Study Overview

Study Details

Study overview

We intend, with this study, to prove that blocking the molecular mechanisms whose blockade prevents VIDD in animals, will indeed prevent the development of VIDD in humans as well. We believe that this evidence will serve as the required basis for proceeding with large, ICU-based clinical trial(s) of a drug to prevent VIDD.

A Clinical Trial of JAK Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Janus Kinase Inhibition to Prevent Ventilator-induced Diaphragm Dysfunction

Condition
Diaphragm Injury
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University Medical Center, Stanford, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients undergoing esophagectomy
  • * Patients with more than mild pulmonary dysfunction
  • * Patients with any neuromuscular disease that might compromise diaphragm function
  • * Patients with abnormal liver or kidney function
  • * Patients taking any immunosuppressant medication (including prednisone) or antifungal medications
  • * History of tuberculosis
  • * Weight loss of \>5% of body weight over previous 6 months
  • * Pregnancy

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Joseph Shrager, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2026-11-30