RECRUITING

Insulin Regulation of Lipolysis and Lipolysis Proteins

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.

Official Title

Insulin Regulation of Lipolysis and Lipolysis Proteins

Quick Facts

Study Start:2018-11-12
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03866408

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Men and Women between the ages of 18 and 55.
  2. * Women will be premenopausal
  3. * Non obese adults BMI between 18-25
  4. * Obese BMI 30-38
  5. * Initiation in patients with established New York Heart Associations (NYHA) class III or IV Heart failure.
  6. * Use in patients with known hypersensitivity to pioglitazone or any other component of ACTOSE.
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Michael D Jensen
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Michael D Jensen, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-11-12
Study Completion Date2024-12

Study Record Updates

Study Start Date2018-11-12
Study Completion Date2024-12

Terms related to this study

Keywords Provided by Researchers

  • adipose tissue

Additional Relevant MeSH Terms

  • Obesity