Insulin Regulation of Lipolysis and Lipolysis Proteins

Description

These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.

Conditions

Obesity

Study Overview

Study Details

Study overview

These studies will define the abnormalities in the adipocyte proteins that are involved in the failure of insulin to suppress lipolysis normally in humans with upper body obesity and will help discover the mechanism by which pioglitazone, a medication used to treat type 2 diabetes and improve insulin resistance, improves insulin-regulation of adipocyte fatty acid metabolism.

Insulin Regulation of Lipolysis and Lipolysis Proteins

Insulin Regulation of Lipolysis and Lipolysis Proteins

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Men and Women between the ages of 18 and 55.
  • * Women will be premenopausal
  • * Non obese adults BMI between 18-25
  • * Obese BMI 30-38
  • * Initiation in patients with established New York Heart Associations (NYHA) class III or IV Heart failure.
  • * Use in patients with known hypersensitivity to pioglitazone or any other component of ACTOSE.

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Michael D Jensen, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2024-12