RECRUITING

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is no established standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the feasibility and efficacy of these cognitive treatments in individuals with brain tumors remains unclear.

Official Title

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Quick Facts

Study Start:2019-06-07
Study Completion:2026-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03948490

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Histologically confirmed low grade supratentorial primary brain tumor
  2. * \>= 18 years old
  3. * Life expectancy \> 12 weeks
  4. * Karnofsky performance status (KPS) \>= 70
  5. * Must speak and be able to read English fluently
  6. * Must have access to the internet
  7. * Must have text enabled cellphone
  8. * Must be receiving MRI scans at University of California, San Francisco (UCSF)
  9. * Must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 3 months
  10. * Must be \>= 6 months from craniotomy
  11. * Must have subjective complaints of cognitive deficits
  12. * Must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics
  13. * Must score \<= 1 SD below normal on ≥ 2 or more domains of baseline neuropsychological assessments
  1. * Diagnosis or evidence of any of the following:
  2. * • Glioblastoma
  3. * • Extra-axial disease (i.e. meningioma)
  4. * • Infra-tentorial disease
  5. * Are not able to comply with study and/or follow-up procedures
  6. * Are unable to complete or score \>= 3 cognitive tests at baseline, which is indicative that patients would be unable to complete the cognitive rehabilitation interventions
  7. * Are acutely suicidal, psychotic, and/or gravely disabled.
  8. * Patients who, based on the neuropsychologist's opinion, are unable to participate in cognitive testing and/or cognitive rehab secondary to significant neurologic deficit

Contacts and Locations

Study Contact

Jennie Taylor, MD, MPH
CONTACT
415-353-2966
jennie.taylor@ucsf.edu

Principal Investigator

Jennie Taylor, MD, MPH
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California, San Francisco
San Francisco, California, 94143
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • Jennie Taylor, MD, MPH, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-06-07
Study Completion Date2026-03-31

Study Record Updates

Study Start Date2019-06-07
Study Completion Date2026-03-31

Terms related to this study

Keywords Provided by Researchers

  • cognitive impairment
  • quality of life

Additional Relevant MeSH Terms

  • Low-grade Glioma