Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Description

Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is no established standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the feasibility and efficacy of these cognitive treatments in individuals with brain tumors remains unclear.

Conditions

Low-grade Glioma

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Study Overview

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Study Details

Study overview

Patients with glial brain tumors have increasingly improved outcomes, with median survival of 5-15 years. However, the treatments, including surgery, radiation, and chemotherapy, often lead to impaired attention, working memory, and other cognitive functions. These cognitive deficits frequently have significant impact on patient quality of life. Although currently, there is no established standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the feasibility and efficacy of these cognitive treatments in individuals with brain tumors remains unclear.

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

Condition
Low-grade Glioma
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Histologically confirmed low grade supratentorial primary brain tumor
  • * \>= 18 years old
  • * Life expectancy \> 12 weeks
  • * Karnofsky performance status (KPS) \>= 70
  • * Must speak and be able to read English fluently
  • * Must have access to the internet
  • * Must have text enabled cellphone
  • * Must be receiving MRI scans at University of California, San Francisco (UCSF)
  • * Must be clinically stable and off treatment (e.g. radiation or chemotherapy) for ≥ 3 months
  • * Must be \>= 6 months from craniotomy
  • * Must have subjective complaints of cognitive deficits
  • * Must have adequate seizure control and be on a stable, or decreasing, dose of anti-epileptics
  • * Must score \<= 1 SD below normal on ≥ 2 or more domains of baseline neuropsychological assessments
  • * Diagnosis or evidence of any of the following:
  • * • Glioblastoma
  • * • Extra-axial disease (i.e. meningioma)
  • * • Infra-tentorial disease
  • * Are not able to comply with study and/or follow-up procedures
  • * Are unable to complete or score \>= 3 cognitive tests at baseline, which is indicative that patients would be unable to complete the cognitive rehabilitation interventions
  • * Are acutely suicidal, psychotic, and/or gravely disabled.
  • * Patients who, based on the neuropsychologist's opinion, are unable to participate in cognitive testing and/or cognitive rehab secondary to significant neurologic deficit

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Jennie Taylor, MD, MPH, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-03-31