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Pulmonary Hemodynamics During Exercise - Research Network

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Pulmonary Circulation Diseases

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this Clinical Research Collaboration is to investigate the prognostic implications of pulmonary hemodynamics during exercise based on a large scale multi-centre approach by using retrospective and prospective analysis of hemodynamic data.

Official Title

Pulmonary Hemodynamics During Exercise - Research Network

Quick Facts

Study Start:2018-12-01
Study Completion:2029-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03954574

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients (females and males; age: above 18yrs) with intermediate or high echocardiographic probability of PH and/or unexplained dyspnea, and/or associated conditions for PAH as clinical indication for RHC at rest and exercise
  2. * Written informed consent of participating subjects after being fully briefed (for prospective analysis)
  1. * Patients with incomplete hemodynamic data at rest or exercise
  2. * Patients without sufficient follow-up data (information on survival / lung transplantation)
  3. * advanced tumour disease or other diseases with a short life expectancy, except pulmonary vascular diseases
  4. * advanced heart failure with pulmonary arterial wedge pressure (PAWP) \> 18 mmHg at rest
  5. * uncontrolled systemic arterial hypertension (RR values \> 160/100 mmHg at rest)
  6. * FEV1\<50% predicted
  7. * TLC\<60% predicted

Contacts and Locations

Study Contact

Gabor Kovacs, MD
CONTACT
+43-316-385
gabor.kovacs@klinikum-graz.at

Principal Investigator

Horst Olschewski, MD
STUDY_CHAIR
Medical University of Graz
Philippe Herve, MD
STUDY_CHAIR
Centre Chirugical Marie Lannelongue

Study Locations (Sites)

University of Arizona, Banner University Medical Center
Phoenix, Arizona, 85724
United States
University of California, Los Angeles, Lung & Heart-Lung Transplant and Pulmonary Hypertension Programs, David Geffen School of Medicine
Los Angeles, California, 90095
United States
Johns Hopkins Hospital, Advanced HF, MCS, Transplant Cardiology, Baltimore, Maryland, USA
Baltimore, Maryland, 21287
United States
Massachusetts General Hospital, Cardiology Division and Pulmonary Unit
Boston, Massachusetts, 02114
United States
Harvard Medical School, Brigham and Women's Hospital
Boston, Massachusetts, 02138
United States
University of Minnesota Medical School, Division of Cardiology, Department of Medicine, Lillehei Heart Institute Minneapolis, Minnesota, USA
Minneapolis, Minnesota, 55455
United States
Mayo Clinic, Division of Cardiovascular Diseases, Department of Medicine
Rochester, Minnesota, 85259
United States
Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of Graz

  • Horst Olschewski, MD, STUDY_CHAIR, Medical University of Graz
  • Philippe Herve, MD, STUDY_CHAIR, Centre Chirugical Marie Lannelongue

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2018-12-01
Study Completion Date2029-12-31

Study Record Updates

Study Start Date2018-12-01
Study Completion Date2029-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Pulmonary Circulation Diseases