RECRUITING

S-Nitrosylation (SNO) Therapy During Autologous Blood Transfusion

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Purpose of the study is to test the hypothesis that administration of an S-nitrosylating (SNO) agent can improve tissue oxygenation during transfusion of packed red blood cells (RBCs).

Official Title

Phase 1 Study of S-Nitrosylation Therapy to Improve Tissue Oxygenation During Autologous Blood Transfusion in Healthy Volunteer

Quick Facts

Study Start:2019-07-25
Study Completion:2028-02-29
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT03999229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 35 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

James D Reynolds, PhD
CONTACT
216-844-3267
jxr343@case.edu
Batuhan Degis, MD
CONTACT
216-334-9277
Batuhan.Degis@UHhospitals.org

Principal Investigator

Mada Helou, MD
PRINCIPAL_INVESTIGATOR
University Hospitals Cleveland Medical Center
Batuhan Degis, MD
STUDY_DIRECTOR
Case Western Reserve University

Study Locations (Sites)

University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106
United States

Collaborators and Investigators

Sponsor: James Reynolds

  • Mada Helou, MD, PRINCIPAL_INVESTIGATOR, University Hospitals Cleveland Medical Center
  • Batuhan Degis, MD, STUDY_DIRECTOR, Case Western Reserve University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2019-07-25
Study Completion Date2028-02-29

Study Record Updates

Study Start Date2019-07-25
Study Completion Date2028-02-29

Terms related to this study

Keywords Provided by Researchers

  • S-Nitrosylation
  • Tissue Oxygenation
  • Anemia-induced tissue hypoxia
  • Red blood cell Transfusion

Additional Relevant MeSH Terms

  • Transfusion Related Complication