Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Eligibility Criteria

• * Age \>= 18 years
• * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2
• * Diagnosis of the following, based on clinical and radiographic evidence:
• * A diffuse glioma, or a prior diagnosis of a diffuse glioma. Diffuse gliomas include diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, oligodendroglioma and anaplastic oligodendroglioma
• * Metastatic brain tumor of any primary origin
• * Epileptic focus requiring surgical resection
• * Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor (primary or metastatic) or epileptic focus as part of routine clinical care
• * Willing to undergo neurosurgical resection or biopsy at Mayo Clinic (Rochester, Minnesota \[MN\])
• * Ability to understand and the willingness to sign a written informed consent document
• * Vulnerable populations: pregnant women, prisoners or the mentally handicapped
• * Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness