RECRUITING

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

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Conditions

Anaplastic AstrocytomaAnaplastic OligodendrogliomaDiffuse AstrocytomaDiffuse GliomaGlioblastomaMetastatic Malignant Neoplasm in the BrainOligodendroglioma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intraoperative microdialysis during neurosurgery for central nervous system malignancies. A biomarker is a measurable indicator of the severity or presence of disease state. Information collected in this study may help doctors to develop new strategies to better diagnose, monitor, and treat brain tumors.

Official Title

Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Quick Facts

Study Start:2020-01-01
Study Completion:2027-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04047264

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age \>= 18 years
  2. * Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0, 1 or 2
  3. * Diagnosis of the following, based on clinical and radiographic evidence:
  4. * A diffuse glioma, or a prior diagnosis of a diffuse glioma. Diffuse gliomas include diffuse astrocytoma, anaplastic astrocytoma, glioblastoma, oligodendroglioma and anaplastic oligodendroglioma
  5. * Metastatic brain tumor of any primary origin
  6. * Epileptic focus requiring surgical resection
  7. * Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor (primary or metastatic) or epileptic focus as part of routine clinical care
  8. * Willing to undergo neurosurgical resection or biopsy at Mayo Clinic (Rochester, Minnesota \[MN\])
  9. * Ability to understand and the willingness to sign a written informed consent document
  1. * Vulnerable populations: pregnant women, prisoners or the mentally handicapped
  2. * Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness

Contacts and Locations

Principal Investigator

Terence C Burns, M.D., Ph.D.
PRINCIPAL_INVESTIGATOR
Mayo Clinic in Rochester

Study Locations (Sites)

Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Terence C Burns, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic in Rochester

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-01-01
Study Completion Date2027-09-01

Study Record Updates

Study Start Date2020-01-01
Study Completion Date2027-09-01

Terms related to this study

Additional Relevant MeSH Terms

  • Anaplastic Astrocytoma
  • Anaplastic Oligodendroglioma
  • Diffuse Astrocytoma
  • Diffuse Glioma
  • Glioblastoma
  • Metastatic Malignant Neoplasm in the Brain
  • Oligodendroglioma