ACTIVE_NOT_RECRUITING

Progressive Abduction Loading Therapy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm. Participants with acute/subacute stroke will receive one of two study interventions in addition to prescribed therapies in both inpatient rehabilitation and day-rehab. Participants will be followed for 1 year.

Official Title

Progressive Abduction Loading Therapy: A Phase IIb Stroke Rehabilitation Trial With Longitudinal Tracking

Quick Facts

Study Start:2021-08-27
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04118998

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Hemiparesis confined to one side, (CMSA Stage 2 or 3 out of 7)
  2. 2. Stroke impacting parenchyma of the middle cerebral artery distribution
  3. 3. Within 90 days post-stroke
  4. 4. 18 to 85 years old
  5. 5. No or Mild-to-moderate Aphasia (NIHSS #9 Best Language. = 0 or 1- Describe picture; No or Mild-to-moderate Aphasia)
  6. 6. No or Mild extinction and inattention (NIHSS 11 Extinction and Inattention. = 0 or 1- No abnormality or Inattention to one modality.)
  7. 7. Ability to perform a 3-step motor command with the unaffected arm
  8. 8. Capacity to provide informed consent
  1. 1. Premorbid and persistent disability or motor impairment of the upper extremities
  2. 2. Brainstem and/or cerebellar lesion
  3. 3. Comorbidity medically contraindicating motor assessments
  4. 4. Any other chronic neurological condition
  5. 5. Pain or hypersensitivity limiting motor assessments
  6. 6. Limb edema limiting study motor assessments

Contacts and Locations

Principal Investigator

Michael D Ellis, PT, DPT
PRINCIPAL_INVESTIGATOR
Northwestern University

Study Locations (Sites)

Department of Physical Therapy and Human Movement Sciences
Chicago, Illinois, 60611
United States
Shirley Ryan AbilityLab
Chicago, Illinois, 60611
United States
Northwestern Medicine Marianjoy Rehabilitation Hospital
Wheaton, Illinois, 60187
United States

Collaborators and Investigators

Sponsor: Northwestern University

  • Michael D Ellis, PT, DPT, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-08-27
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2021-08-27
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • Rehabilitation
  • Arm
  • Flexion Synergy
  • Longitudinal
  • Targetted
  • Quantitative

Additional Relevant MeSH Terms

  • Stroke, Acute