Progressive Abduction Loading Therapy

Description

This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm. Participants with acute/subacute stroke will receive one of two study interventions in addition to prescribed therapies in both inpatient rehabilitation and day-rehab. Participants will be followed for 1 year.

Conditions

Stroke, Acute

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Study Overview

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Study Details

Study overview

This study attempts to minimize the development of a common movement impairment following stroke known as "flexion synergy" that makes it extremely difficult to reach outward with the arm. Participants with acute/subacute stroke will receive one of two study interventions in addition to prescribed therapies in both inpatient rehabilitation and day-rehab. Participants will be followed for 1 year.

Progressive Abduction Loading Therapy: A Phase IIb Stroke Rehabilitation Trial With Longitudinal Tracking

Progressive Abduction Loading Therapy

Condition
Stroke, Acute
Intervention / Treatment

-

Contacts and Locations

Chicago

Department of Physical Therapy and Human Movement Sciences, Chicago, Illinois, United States, 60611

Chicago

Shirley Ryan AbilityLab, Chicago, Illinois, United States, 60611

Wheaton

Northwestern Medicine Marianjoy Rehabilitation Hospital, Wheaton, Illinois, United States, 60187

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Hemiparesis confined to one side, (CMSA Stage 2 or 3 out of 7)
  • 2. Stroke impacting parenchyma of the middle cerebral artery distribution
  • 3. Within 90 days post-stroke
  • 4. 18 to 85 years old
  • 5. No or Mild-to-moderate Aphasia (NIHSS #9 Best Language. = 0 or 1- Describe picture; No or Mild-to-moderate Aphasia)
  • 6. No or Mild extinction and inattention (NIHSS 11 Extinction and Inattention. = 0 or 1- No abnormality or Inattention to one modality.)
  • 7. Ability to perform a 3-step motor command with the unaffected arm
  • 8. Capacity to provide informed consent
  • 1. Premorbid and persistent disability or motor impairment of the upper extremities
  • 2. Brainstem and/or cerebellar lesion
  • 3. Comorbidity medically contraindicating motor assessments
  • 4. Any other chronic neurological condition
  • 5. Pain or hypersensitivity limiting motor assessments
  • 6. Limb edema limiting study motor assessments

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Northwestern University,

Michael D Ellis, PT, DPT, PRINCIPAL_INVESTIGATOR, Northwestern University

Study Record Dates

2025-08-31